anti-FAK (Focal adhesion kinase 1), Rabbit Monoclonal (RM472)

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RevMab Biosciences
Product Code: REV-31-1364-00
Product Group: Primary Antibodies
CodeSizePrice
REV-31-1364-00-R100100 ul£455.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Recombinant Antibody
Antibody Clone: RM472
Regulatory Status: RUO
Target Species: Human
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
BLUE ICE
Storage:
Long term storage:-20°C.

Images

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Immunohistochemical staining of formalin fixed and paraffin embedded human lung cancer tissue sections using Anti-FAK antibody (RM472) at 1:100 dilution.
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Immunohistochemical staining of formalin fixed and paraffin embedded human lung cancer tissue sections using Anti-FAK antibody (RM472) at 1:100 dilution.

Documents

Further Information

Alternate Names/Synonyms:
Focal Adhesion Kinase 1; Protein-tyrosine Kinase 2; PTK2
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
A peptide corresponding to residues surrounding Tyr397 of human FAK1 (Focal adhesion kinase 1).
Long Description:
Recombinant Antibody. RM472 reacts to human FAK (Focal adhesion kinase 1). This antibody may also react to mouse or rat FAK, as predicted by immunogen homology. Isotype: Rabbit IgG. Immunogen: A peptide corresponding to residues surrounding Tyr397 of human FAK1 (Focal adhesion kinase 1). Applications: IHC, WB. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. FAK1 (Focal Adhesion Kinase 1) is a non-receptor protein tyrosine kinase that is involved in the regulation of cell adhesion, migration, and survival. It is a member of the Src family of kinases. FAK1 is activated by binding to integrins, which are transmembrane proteins that mediate the attachment of cells to the extracellular matrix. When FAK1 is activated, it phosphorylates a number of downstream targets, including paxillin, tensin, and the small GTPase Ras. These phosphorylation events lead to the activation of a number of signaling pathways, including the MAPK pathway, the PI3K-AKT pathway, and the NF-kappaB pathway. The MAPK pathway is involved in the regulation of cell migration, survival, and proliferation. The PI3K-AKT pathway is involved in the regulation of cell survival and metabolism. The NF-kappaB pathway is involved in the regulation of inflammation and immunity.
NCBI Uniprot Number:
Q05397
Package Type:
Vial
Product Description:
FAK1 (Focal Adhesion Kinase 1) is a non-receptor protein tyrosine kinase that is involved in the regulation of cell adhesion, migration, and survival. It is a member of the Src family of kinases. FAK1 is activated by binding to integrins, which are transmembrane proteins that mediate the attachment of cells to the extracellular matrix. When FAK1 is activated, it phosphorylates a number of downstream targets, including paxillin, tensin, and the small GTPase Ras. These phosphorylation events lead to the activation of a number of signaling pathways, including the MAPK pathway, the PI3K-AKT pathway, and the NF-kappaB pathway. The MAPK pathway is involved in the regulation of cell migration, survival, and proliferation. The PI3K-AKT pathway is involved in the regulation of cell survival and metabolism. The NF-kappaB pathway is involved in the regulation of inflammation and immunity.
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
RM472 reacts to human FAK (Focal adhesion kinase 1). This antibody may also react to mouse or rat FAK, as predicted by immunogen homology.
Transportation:
Non-hazardous
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.