anti-Stat6, Rabbit Monoclonal (RM473)

Signal Transducer and Activator of Transcription 6

32160000

liquid

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.

Avoid freeze/thaw cycles.

A peptide corresponding to residues near the C-terminus of human Stat6.

Recombinant Antibody. RM473 reacts to human Stat6. Isotype: Rabbit IgG. Immunogen: A peptide corresponding to residues near the C-terminus of human Stat6. Applications: IHC, WB. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. STAT6 (Signal transducer and activator of transcription 6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins. The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene expression. STAT6 is activated by the binding of interleukin-4 (IL-4) to its receptor. IL-4 is a cytokine that is produced by T cells, B cells, and mast cells. When IL-4 binds to its receptor, it triggers a series of events that lead to the phosphorylation of STAT6. Phosphorylated STAT6 then dimerizes and translocates to the nucleus, where it binds to DNA and activates the transcription of a number of genes. The genes that are activated by STAT6 play a role in a number of different biological processes, including Th2 cell differentiation, IgE production, eosinophil differentiation, mast cell activation and is involved in the development of some types of cancer.

P42226

Vial

STAT6 (Signal transducer and activator of transcription 6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins. The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene expression. STAT6 is activated by the binding of interleukin-4 (IL-4) to its receptor. IL-4 is a cytokine that is produced by T cells, B cells, and mast cells. When IL-4 binds to its receptor, it triggers a series of events that lead to the phosphorylation of STAT6. Phosphorylated STAT6 then dimerizes and translocates to the nucleus, where it binds to DNA and activates the transcription of a number of genes. The genes that are activated by STAT6 play a role in a number of different biological processes, including Th2 cell differentiation, IgE production, eosinophil differentiation, mast cell activation and is involved in the development of some types of cancer.

Protein A purified.

Rabbit

RM473 reacts to human Stat6.

Non-hazardous

12352203

Stable for at least 1 year after receipt when stored at -20°C.