anti-Trimethyl-Histone H3 (Lys36), Rabbit Monoclonal (RM491)
| Code | Size | Price |
|---|
| REV-31-1383-00-C100 | 100 ug | £553.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Recombinant Antibody
Antibody Clone: RM491
Regulatory Status: RUO
Target Species:
- Human
- Vertebrates
Applications:
- ChIP
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Multiplex
Shipping:
BLUE ICE
Storage:
Long term storage:-20°C.
Documents
Further Information
Alternate Names/Synonyms:
H3 K36me3
Concentration:
1 mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
A trimethyl-peptide corresponding to trimethyl-Histone H3 (Lys36).
Long Description:
Recombinant Antibody. RM491 reacts to Histone H3 trimethylated at Lysine 36 (K36me3). No cross-reactivity with monomethylated Lysine 36 (K36me1) or dimethylated Lysine 36 (K36me2) or other methylations in histone H3. Isotype: Rabbit IgG. Immunogen: A trimethyl-peptide corresponding to trimethyl-Histone H3 (Lys36). Applications: ELISA, CHIP, Multiplex. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Histone H3 has three main variants, H3.1 and H3.2, which are deposited in chromatin only during DNA replication and H3.3, which is replication independent and is found primarily in the regions of active transcription and heterochromatin. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
Package Type:
Vial
Product Description:
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Histone H3 has three main variants, H3.1 and H3.2, which are deposited in chromatin only during DNA replication and H3.3, which is replication independent and is found primarily in the regions of active transcription and heterochromatin. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
RM491 reacts to Histone H3 trimethylated at Lysine 36 (K36me3). No cross-reactivity with monomethylated Lysine 36 (K36me1) or dimethylated Lysine 36 (K36me2) or other methylations in histone H3.
Transportation:
Non-hazardous
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.