Anti-Human CD2 - Purified in vivo GOLD™ Functional Grade
| Code | Size | Price |
|---|
| LEI-C365-1.0mg | 1.0 mg | £175.00 |
Quantity:
| LEI-C365-5.0mg | 5.0 mg | £380.00 |
Quantity:
| LEI-C365-25mg | 25 mg | £1,014.00 |
Quantity:
| LEI-C365-50mg | 50 mg | £1,556.00 |
Quantity:
| LEI-C365-100mg | 100 mg | £2,159.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: G11
Regulatory Status: RUO
Target Species: Human
Applications:
- Co-stimulation
- Flow Cytometry
- Immunohistochemistry (IHC)
- In Vivo Assay
- Western Blot (WB)
Shipping:
2-8°C
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Further Information
Antigen Distribution:
CD2 is present on normal peripheral blood lymphocytes, thymocytes, mature circulating T-cells and a subset of NK cells.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
in vivo GOLD™, Purified in vivo Functional Grade
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Not available or unknown
Long Description:
CD2 is a 45-59 kD type I transmembrane glycoprotein belonging to the Ig superfamily. CD2 is the receptor for LFA-3/CD58. CD2 serves as an adhesion receptor that binds to CD58; generating the activation of CD2-positive T cells and NK cells and in the regulation of their cytolytic activities. CD2 is a specific marker for T cells and NK cells. Hence, it can be used in immunohistochemistry to identify the occurrence of these cells in tissue sections. The vast majority of T cell lymphomas and leukemias express CD2 which makes it possible to distinguish these conditions from B-cell lymphomas.
NCBI Gene:
914
Purity:
?95% monomer by analytical SEC, >95% by SDS Page
Target:
CD2
References
1. Stern, LJ. et al. (2005) Proc Natl Acad Sci U S A.102(10):3744-9 PubMed
2. Woetmann, Anders et al. (2010) Experimental Dermatology 19: 1096?1102. Article Link
3. Meuer, S.C. et al. (1984) Cell 36:897
4. Peterson, A. and Sneed, B. (1987) Nature 329:842
5. Bierer, B.E. et al. (1989) Annu. Rev Immunol. 7:579
6. Krensky, C.F. et al. (1982) Proc. Natl. Acad. Sci. USA 79:7489
7. Krensky, C.F. et al. (1983) J. Immunol. 131:611
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