Anti-Human CD14 - Purified in vivo GOLD™ Functional Grade
| Code | Size | Price |
|---|
| LEI-C370-1.0mg | 1.0 mg | £175.00 |
Quantity:
| LEI-C370-5.0mg | 5.0 mg | £380.00 |
Quantity:
| LEI-C370-25mg | 25 mg | £1,014.00 |
Quantity:
| LEI-C370-50mg | 50 mg | £1,556.00 |
Quantity:
| LEI-C370-100mg | 100 mg | £2,159.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: UCHM-1
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- In Vivo Assay
- Western Blot (WB)
Shipping:
2-8°C
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Further Information
Antigen Distribution:
CD14 is expressed on monocytes, macrophages, dendritic cells, and granulocytes.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
in vivo GOLD™, Purified in vivo Functional Grade
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Long Description:
CD14 is a 53-55 kD GPI-anchored single chain glycoprotein that plays a role in the clearance of gram-negative pathogens by interacting with other proteins, including TLR-4 and MD-2, to mediate the innate immune response to bacterial lipopolysaccharide (LPS). As a high-affinity receptor for LPS, it is involved in the upregulation of adhesion molecules and cytokine expression in monocytes and neutrophils.
NCBI Gene:
929
Purity:
?95% monomer by analytical SEC, >95% by SDS Page
Target:
CD14
References
1. Ulrich Costabel et al. (1995) CHEST 108: 1614
2. Ulevitch RJ et al. (1993) Immunobiology 187: 227
3. Schumann RR et al. (1994) Medical Microbiol Immunol. 183: 279
4. Verhasselt V et al. (1997) J Immunol. 158: 2919
5. Kirkland TN et al. (2000) J Biol Chem. 275: 3144
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