Anti-Human CD16 - Purified
| Code | Size | Price |
|---|
| LEI-C465-0.1mg | 0.1 mg | £485.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: GRM1
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Immunoprecipitation (IP)
- Western Blot (WB)
Further Information
Antigen Distribution:
CD16 is expressed on NK cells, activated monocytes, macrophages, neutrophils, and placental trophoblasts.
Concentration:
0.1 mg/ml
Conjugate/Tag/Label:
Purified
Long Description:
CD16 is expressed in two forms: CD16a and CD16b. CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. CD16b (FcγRIIIB) is a 48 kD GPI-anchored protein whose extracellular domain is over 95% homologous to that of CD16a. CD16 regulates both phagocytosis and antibody-dependent cell-mediated cytotoxicity. It has been reported that CD16 is involved in Natural Killer Cell activation and plays a role in signal transduction. The receptors, CD32 (FcγRIII) and CD16 (FcγRII), are 40-60 kD and bind antibody-antigen immune complexes and mediate adaptive immune responses.
NCBI Gene:
2214
Target:
CD16
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