Anti-Mouse CD11a (LFA-1α) (Clone I21/7) - Purified
Code | Size | Price |
---|
LEI-C223-100ug | 100 ug | £135.00 |
Quantity:
LEI-C223-500ug | 500 ug | £250.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2a κ
Antibody Clonality: Monoclonal
Antibody Clone: I21/7
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
Ambient
Storage:
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Further Information
Antigen Distribution:
CD11a is present on thymocytes, blood lymphocytes, bone marrow cells and certain lymphoma and macrophage-like cell lines.
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified
Format:
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Long Description:
LFA-1α (CD11a) and CD18 are the Integrin alpha-L and beta-2 chains respectively that combine to form LFA-1, a glycoprotein and a member of the Integrin family. Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3, ICAM4 and for F11R. LFA-1 participates in the immunological synapses between CD8+ T lymphocytes and antigen-presenting cells. The absence of LFA-1α or β may induce LAD. The antigen contributes to natural killer cell cytotoxicity, and is involved in various immune phenomena such as leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. The CD11b/CD18 antigen is a heterodimeric surface glycoprotein on leukocytes and belongs to the β2 integrin family. CD11b functions as a receptor for C3bi complement, clotting factor X, fibrinogen and ICAM-1. CD11c forms an α/β heterodimeric glycoprotein (CD11c/CD18 complex) which belongs to the β2 integrin family. The complex binds fibrinogen and reportedly serves as a receptor for iC3b and ICAM-1. During inflammatory responses, it mediates cell to cell interaction and is important in both monocyte adhesion and chemotaxis.
NCBI Gene:
16408
Target:
CD11a
References
1. Trowbridge, I.S. et al. (1981) J. Exp. Med. 154:1517
2. Springer, T. et al. (1982) Immunol. Rev. 68: 171
3. Wuthrich, R. P. et al. (1991) Cell Immunol. 144:22
3. Falanga, P. B. et al. (1991) Eur. J. Immunol. 21: 2259
4. Talento, A. et al. (1993) Transplantation. 55: 418
5. Barret, T.B. et al. (1991) J. Immunol. 146: 1722
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