Anti-Mouse CD25 - Purified
| Code | Size | Price |
|---|
| LEI-C1189-100ug | 100 ug | £121.00 |
Quantity:
| LEI-C1189-500ug | 500 ug | £165.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG1 λ
Antibody Clonality: Monoclonal
Antibody Clone: PC61
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Blocking
- Depletion
- Flow Cytometry
- Functional Study
- Immunohistochemistry- Frozen Section (IHC-F)
- Immunoprecipitation (IP)
- Western Blot (WB)
Shipping:
Ambient
Storage:
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Further Information
Antigen Distribution:
CD25 is expressed in activated T cells and B cells, thymocyte subset, pre-B cells, T regulatory cells.
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified
Format:
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Immunogen:
IL-2-dependent cytolytic mouse T-cell clone B6.1
Long Description:
CD25, a 55 kD type I transmembrane glycoprotein, has been shown to play roles in lymphocyte differentiation, activation, and proliferation. Many resting memory T cells constitutively express IL2RA. It functions as the receptor for HTLV-1, resulting in its expression on neoplastic cells in adult T cell lymphoma/leukemia. CD25 (sIL-2R) has been used to track disease progression. Some additional clinical applications include Chagas disease, a disease characterized by a decline of CD25 expression on immune cells, and Multiple sclerosis, in which treatments with mAbs target CD25.
NCBI Gene:
16184
Target:
CD25
References
1. Warren J. Leonard et al. (2002) The EMBO Journal 21: 3051
2. FW Alt et al. (1995) Immnnity 3: 521
3. Greene WC et al. (1990) J Invest Dermatol. 94: 27S