Anti-Human Caspase-3 Active Subunit (p17)
| Code | Size | Price |
|---|
| LEI-C1141-0.2mg | 0.2 mg | £313.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: C31.129
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
2-8°C
Storage:
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Further Information
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified
Format:
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Long Description:
Caspase-3 is a member of the caspase family of cysteine proteases and plays a key role in mediating Fas (CD95) and tumor necrosis factor?1 (TNFR-1) induced apoptosis. Caspases can be divided into three groups: apoptotic initiators, apoptotic executioners, and inflammatory mediators.1,2 Caspase-3 is activated during apoptotic signaling events by upstream proteases including caspase 6 and caspase 8.3 Caspase-3 is thought to be essential for chromatin margination, DNA fragmentation and nuclear collapse during apoptosis.3
Target:
Caspase-3 Active Subunit (p17)
References
1. Adadah, BA. et al. (2000) Journal of Neurotoma 17(10): 811 2. Salvesen, GS. et al. (1999) Proc. Natl. Acad. Sci. USA 96(20): 10964 3. Slee, EA. et al. (2001) J. Biol. Chem. 276(10):7320