Anti-Human CCR8 (EL)
| Code | Size | Price |
|---|
| LEI-C1119-20ug | 20 ug | £221.00 |
Quantity:
| LEI-C1119-0.1mg | 0.1 mg | £574.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
Ambient
Storage:
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Formulation:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Long Description:
CCR8 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human and mouse CCR8 were cloned and designated TER1, CKR-L1, and ChemR1. The encoded seven transmembrane protein was identified as the receptor for human CC chemokine I-309 and renamed CCR8. Recently, CCR8 was found to serve as a coreceptor for diverse T-cell tropic, dual-tropic and macrophage-tropic HIV-1 strains. CCR8 mediates CC chemokine I-309 induced monocyte chemoattraction and HIV-1 envelope fusion and virus infection, which can be prevented by the CCR8 ligand I-309. CCR8 is expressed in spleen, thymus and T lymphoblastic cell lines.
Target:
CCR8
References
1. Napolitano, M. et al. (1996) J. Immunol. 157:2759
2. Zaballos, A. et al. (1996) Biochem. Biophys. Res. Commun. 227:846
3. Samson, M. et al. (1996) Eur. J. Immunol. 26:3021
4. Goya, I. et al. (1998) J. Immunol. 160:1975