Recombinant Human EDAR
| Code | Size | Price |
|---|
| LEI-E191-100ug | 100 ug | £648.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Ectodysplasin A receptor (EDAR), also known as ED1R, is a cell surface receptor of the tumor necrosis factor receptor (TNFR) family. Defects in EDAR are a cause of hypohidrotic ectodermal dysplasia (HED).1 It is characterized by abnormalities in the hair, teeth and sweat glands. EDAR is also the genetic determinant of hair fiber thickness variation among Asian populations.2 EDA has two splice variants, EDA-A1 and EDA-A2, which differ by only two amino acids. Despite this minor difference, EDAR only binds to EDA-A1, whereas EDA-A2 binds to XEDAR. It mediates the activation of NF-κB and JNK and may promote caspase independent cell death.3
NCBI Gene:
10913
Purity:
>90% by SDS-PAGE and analyzed by silver stain.
Target:
EDAR
References
1. Headon, DJ. et al. (2008) Hum. Genet. 29:1405
2. Tokunaga, K. et al. (2008) Hum. Genet. 124:179
3. Kumar, A. et al. (2001) J. Biol. Chem. 276:2668
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