Recombinant Human IL-1 RII
| Code | Size | Price |
|---|
| LEI-I-555-50ug | 50 ug | £739.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Interleukin 1 receptor type II (IL1R2), also known as CD121b, is a transmembrane protein and member of the IL-1 receptor family. It is found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Like IL1R1, IL1R2 can bind all three forms of IL-1 (IL-1α, IL-1β and IL-1RA) but does not transmit IL-1 signals.1 In addition to the membrane-bound form, IL1R2 also exists as the soluble form and either acts as a decoy receptor that inhibits IL-1 action by blocking the binding of IL-1 to the type I receptor complex.2 Furthermore, IL-4 is reported to antagonize the activity of IL-1 by inducing the expression and release of IL1R2. Recombinant soluble IL1R2 is thus a potent antagonist of IL-1 action and serves as a potential therapeutic target.3 IL1R2 is involved in the control of the pro-inflammatory state that takes place in the endometrium during the premenstrual and menstrual periods. IL1R2 can neutralize IL-1β and counteract its effect on endometrial stromal cells, and therefore may provide a new clinical strategy for the treatment of endometriosis.4
NCBI Gene:
7850
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
IL-1 RII
References
1. McMahan, CJ. et al. (1991) Embo. J. 10:2821
2. Colotta, F. et al. (1993) Science 261:472
3. Neumann, D. et al. (2000) J. Immunol. 165:3350
4. Akoum, A. et al. (2005) Hum. Rep. 20:1177
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