Anti-Human IκB Kinase Alpha (CT-1) (IKKα)
| Code | Size | Price |
|---|
| LEI-I-325-20ug | 20 ug | £199.00 |
Quantity:
| LEI-I-325-0.1mg | 0.1 mg | £591.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Shipping:
Ambient
Storage:
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Formulation:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen:
PN:I-313
Long Description:
Nuclear factor κ B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa, and bacteria product LPS. NF-κB is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. The long-sought IκB kinase (IKK), which phosphorylates IκB, and mediates IκB degradation and NF-κB activation, was recently identified by several laboratories.1-4 IKK is a serine protein kinase, and the IKK complex contains α and β subunits (IKKα and IKKβ). IKKa and IKKβ interact with each other and both are essential for the NF-κB activation. IKKα specifically phosphorylates IkB-α. IKKα is expressed in variety of human tissues.
Target:
IκB Kinase Alpha
References
1. DiDonato, JA. et al. (1997) Nature 388:548 2. Regnier, CH. et al. (1997) Cell 90:373 3. Zandi, E. et al. (1997) Cell 91:243 4. Woronicz, JD. et al. (1997) Science 278:866
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