Anti-Human MMP-13 (Clone M31.387)
| Code | Size | Price |
|---|
| LEI-M1088-0.2mg | 0.2 mg | £293.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: M31.387
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
Ambient
Storage:
This antibody may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Further Information
Concentration:
0.1 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This purified antibody is formulated with no carrier proteins or preservatives added in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl.
Formulation:
This purified antibody is formulated with no carrier proteins or preservatives added in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl.
Immunogen:
a synthetic peptide corresponding to amino acids 131 to 140 of human MMP-13
Long Description:
Matrix metallopeptidase 13 (collagenase 3), also known as MMP13, is a glycosylated protein1 and a member of the matrix metalloproteinase (MMP) family of neutral endopeptidases, which is expressed in the skeleton during embryonic development2 and are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. MMP-13 is tightly bound to tissues and utilizes heparan sulfate proteoglycans as extracellular docking molecules. It is produced by many different cell types as an inactive proform that requires proteolytic activation to gain activity.3 Mutations causing lack of MMP-13 expression have been shown to be associated with skeletal disorders characterized by defective growth and modeling of the spine and long bones (spondyloepimetaphyseal dysplasias).4
Target:
MMP-13
References
1. Kn?uper, V. et al. (1996) J Biol. Chem. 271: 17124 2. Krane, SM. et al. (2004) Proc Natl Acad Sci U S A. 101(49):17192-7 3. Woessner, JF. et al. (2000) J Biol. Chem. 275: 4183 4. Kennedy, AM. et al. (2005) J Clin. Invest. 115: 2832
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