Anti-Human NIK (CT)

Product Code: LEI-N131

Code	Size	Price

LEI-N131-20ug

20 ug

£199.00

Quantity:

LEI-N131-0.1mg

0.1 mg

£591.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit

Antibody Clonality: Polyclonal

Regulatory Status: RUO

Target Species: Human

Application: Western Blot (WB)

Shipping:

Ambient

Storage:

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Further Information

Concentration:

0.5 mg/ml

Conjugate/Tag/Label:

Purified No Carrier Protein

Format:

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Formulation:

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Immunogen:

PN:N134

Long Description:

Nuclear factor κ B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα, LPS and mitogens. A serine/threonine protein kinase which mediates NF-κB activation by IL-1, TNFα and CD95 was identified recently and designated NIK (for NF-κB inducing kinase)(1). NIK is an activator of IκB kinase α and β (IKKα and IKKβ)(2-5). Therefore, NIK is a key molecule in the NF-κB signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.

NCBI Gene:

9020

Target:

NIK

References

1. Malinin NL, Boldin MP, Kovalenko AV, Wallach . MAP3Krelated kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature 1997;385:540-544 2. Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M. Identification and characterization of an IkappaB kinase. Cell 1997;90:373-383 3. Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV. IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science 1997;278:866-869 4. Ling L, Cao Z, Goeddel D. NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Proc Natl Acad Sci USA 1998;95:3792-3797 5. Nakano H, Shindo M, Sakon S, Nishinaka S, Mihara M, Yagita H, Okumura K. Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc Natl Acad Sci USA 1998;95:3537-3542 (RD0400)

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NIK (CT) Blocking Peptide	LEI-N134	Leinco Technologies	Summary Details