Anti-Human Tyrosine Kinase Substrate p62^dok (CT)

Product Code: LEI-P161

Code	Size	Price

LEI-P161-20ug

20 ug

£199.00

Quantity:

LEI-P161-0.1mg

0.1 mg

£591.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit

Antibody Clonality: Polyclonal

Regulatory Status: RUO

Target Species: Human

Applications:

Immunohistochemistry- Paraffin Embedded (IHC-P)
Western Blot (WB)

Shipping:

Ambient

Storage:

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Further Information

Concentration:

0.5 mg/ml

Conjugate/Tag/Label:

Purified No Carrier Protein

Format:

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Formulation:

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Immunogen:

PN:P188

Long Description:

Signals from most growth factors and cytokines are transduced by receptor tyrosine kinases or non-receptor tyrosine kinases. Activated tyrosine kinases phosphorylate their substrates, which mediate the cellular response to extracellular stimuli. A long-sought major substrate termed p62dok (downstream of tyrosine kinase) for many tyrosine kinases including c-kit, v-abl, v-Fps, v-Src, v-Fms, and activated EGF, PDGF, IGF, VEGF and insulin receptors was identified recently from human and mouse by several laboratories. Upon phosphorylation, p62dok forms a complex with the ras GTPase-activating protein (RasGAP). p62dok represents a new family with very recently identified p56dok.

Target:

Tyrosine Kinase Substrate p62dok

References

1. Carpino, N. et al. (1997) Cell 88:197 2. Yamanashi, Y. et al. (1997) Cell 88:205 3. Holland, SJ. et al. (1997) EMBO J. 16:3877 4. Di Cristofano, A. et al. (1998) J. Biol. Chem. 273:4827

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