Anti-Human TGF-α
| Code | Size | Price |
|---|
| LEI-T145-25ug | 25 ug | £420.00 |
Quantity:
| LEI-T145-100ug | 100 ug | £694.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Caprine (Goat)
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Neutralisation
- Western Blot (WB)
Shipping:
Ambient
Storage:
The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Further Information
Conjugate/Tag/Label:
Antigen Affinity Purified
Format:
This antigen affinity purified polyclonal antibody has been 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.4 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Formulation:
This antigen affinity purified polyclonal antibody has been 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.4 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Immunogen:
Purified Recombinant Human TGF-α (>98%)
Long Description:
Transforming growth factor alpha (TGF-α) is thought to be the major autocrine factor controlling growth in epidermal cells.1 It plays an important role in cell proliferation during embryogenesis.2 It also stimulates neural cell proliferation in the adult injured brain.3 TGF-alpha is an oncogenic growth factor which drives estrogen independent breast tumor proliferation via an autocrine loop.4 TGF-alpha which normally suppresses tumours can actually be used by cancer cells to enhance their ability to spread. It is present in high levels in around half of all breast tumours, and these tumours tend to be more aggressive and more likely to spread to the lungs. It has been shown that TGF-alpha can prompt breast cancer cells to make another cytokine called angiopoietin-like 4 (ANGPTL4), which helps the cells to spread through the bloodstream.5
NCBI Gene:
7039
Target:
TGF-alpha
References
1. Taylor, HS. et al. (2009) Semin Reprod Med.27(1):62-79
2. Lamaroon, A. et al. (2002) J Dental Research 75:1534
3. Loughlin, S. et al. (2002) Proc Natl Acad Sci USA 97:14686
4. Fuchs, E. et al. (1991) Genes & Dev. 5:714
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