Anti-Human TGF-α - Biotin

Product Code: LEI-T186

Code	Size	Price

LEI-T186-50ug

50 ug

£762.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Caprine (Goat)

Antibody Clonality: Polyclonal

Regulatory Status: RUO

Target Species: Human

Applications:

Enzyme-Linked Immunosorbent Assay (ELISA)
Western Blot (WB)

Shipping:

Ambient

Storage:

The lyophilized biotinylated antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for up to twelve months from date of receipt. The reconstituted biotin conjugate can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted conjugate aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.

Further Information

Conjugate/Tag/Label:

Biotin

Format:

This biotinylated antigen affinity purified polyclonal antibody has been 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.4 containing 50 ug of bovine serum albumin per ug of antibody with no calcium, magnesium, or preservatives present.

Formulation:

Immunogen:

Purified Recombinant Human TGF-α (Accession # P01135)

Long Description:

Transforming growth factor alpha (TGF-α) is thought to be the major autocrine factor controlling growth in epidermal cells.1 It plays an important role in cell proliferation during embryogenesis.2 It also stimulates neural cell proliferation in the adult injured brain.3 TGF-alpha is an oncogenic growth factor which drives estrogen independent breast tumor proliferation via an autocrine loop.4 TGF-alpha which normally suppresses tumours can actually be used by cancer cells to enhance their ability to spread. It is present in high levels in around half of all breast tumours, and these tumours tend to be more aggressive and more likely to spread to the lungs. It has been shown that TGF-alpha can prompt breast cancer cells to make another cytokine called angiopoietin-like 4 (ANGPTL4), which helps the cells to spread through the bloodstream.5

NCBI Gene:

7039

Target:

TGF-α

References

1. Taylor, HS. et al. (2009) Semin Reprod Med.27(1):62-79 2. Lamaroon, A. et al. (2002) J Dental Research 75:1534 3. Loughlin, S. et al. (2002) Proc Natl Acad Sci USA 97:14686 4. Fuchs, E. et al. (1991) Genes & Dev. 5:714