Recombinant Human GM-CSF
Code | Size | Price |
---|
LEI-G124-10ug | 10 ug | £420.00 |
Quantity:
LEI-G124-50ug | 50 ug | £1,217.00 |
Quantity:
LEI-G124-500ug | 500 ug | £2,765.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This protein is stable for up to twelve months when stored at -20°C to -70°C. After thawing and addition of a carrier protein this protein may be stored at 2°C to 8°C for one month or for long-term storage aliquot and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Images
Further Information
Format:
This recombinant protein solution was 0.2 um filtered and formulated in modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives present.
Formulation:
This recombinant protein solution was 0.2 um filtered and formulated in modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives present.
Long Description:
Granulocyte-Macrophage Colony Stimulating Factor is a 22 kD, pleiotropic cytokine that is a white blood cell growth factor. It controls the production and function of blood cells by stimulating stem cells to produce granulocytes and monocytes. GM-CSF differs from G-CSF in that it affects more cell types including macrophages and eosinophils. Moreover, GM-CSF is part of the immune/inflammatory cascade, a process crucial for fighting infection. Interestingly, GM-CSF expression may have pathological implications. Autocrine expression of GM-CSF in myeloid leukemia cells is suspected to play a role in neoplasia, the formation of a new and abnormal growth of tissue. Additionally, GM-CSF expression has also been documented in certain solid tumors. There have also been reports of GM-CSF in synovial fluid from patients with arthritis suggesting that GM-CSF may play a role in tissue damage associated with the inflammatory process. Blocking GM-CSF is thought to have therapeutic potential by reducing inflammation. Some drugs are currently being developed to block GM-CSF.
NCBI Gene:
1437
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
GM-CSF
References
1. Parker, MW. et al. (2008) Cell 134:496
2. Esnault, S. et al. (2002) Arch. Immunol. Ther. Exp. (Warsz.) 50:121
3. Yong, KL. et al. (1993) J. Immunol. 150:2449
4. Whitsett, JA. et al. (2002) Annu. Rev. Physiol. 64:775
5. Armitage, JO. et al. (1992) Sem. Hematol. 29:14
6. Eksioglu, EA. et al. (2007) Exp. Hematol. 35:1163
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