Recombinant Human IL-4
| Code | Size | Price |
|---|
| LEI-I-186-10ug | 10 ug | £420.00 |
Quantity:
| LEI-I-186-20ug | 20 ug | £534.00 |
Quantity:
| LEI-I-186-50ug | 50 ug | £1,126.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives present.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives present.
Long Description:
IL-4 is a 15-19 kD pleiotropic immune cytokine secreted by activated TH2 cells. It has many biological roles, including the regulation in humoral and adaptive immunity, the inhibition of bone resorption, the stimulation of activated B-cell and T-cell proliferation, and initiation of allergic responses. Moreover, IL-4 induces a positive feedback loop by stimulating differentiation of naive helper T cells, or Th0 cells, to Th2 cells which in turn secrete more IL-4. Increased IL-4 production and overproduction of IL-4R are found in many cancers. IL-4 has a significant effect on tumor progression by increasing apoptosis resistance via tumor growth enhancement. IL-4 may also play a part in the immune dysregulation that occurs in most HIV-1 infected patients.
NCBI Gene:
3565
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
IL-4
References
1. ?dum, N. et al. (2001) Blood. 97(4):1056-62. Article Link
2. ?dum, N. et al. (2003) J Biol Chem. 278(5):2787-91. Article Link
3. ?dum, N et al. (2001) Leukemia 15:787?793 Article Link
4. Woetmann, A. et al. (2010) Experimental Dermatology 19:1096?1102. Article Link
5. Pike, JW. et al. (2001) PNAS 98:2443
6. Finkelman, FD. et al. (2003) J. Immunol. 170:3835
7. Paludan, SR. et al. (1998) Scand. J. Immunol. 48:459
8. Ryan, JJ. et al. (2007) Crit. Rev. Immunol. 27:15
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