Recombinant Human IL-11
| Code | Size | Price |
|---|
| LEI-I-194-5ug | 5 ug | £477.00 |
Quantity:
| LEI-I-194-25ug | 25 ug | £1,342.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
2-8°C
Storage:
Working aliquots of this recombinant protein solution are stable for up to six months at -20°C to -70°C in a manual defrost freezer. Upon thawing in the presence of a carrier protein this recombinant protein can be stored at 2° - 8°C for one month without detectable loss of activity. Product shows no detectable loss in activity after 3 months when aliquoted and stored at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles.
Further Information
Format:
This recombinant protein solution was 0.2 um filtered and formulated in modified Dulbecco?s phosphate buffered saline (1X PBS) and 1mM EDTA, pH 7.2 ? 7.4 with no calcium, magnesium, or preservatives present. The final protein concentration is 0.501 mg/ml.
Formulation:
This recombinant protein solution was 0.2 um filtered and formulated in modified Dulbecco?s phosphate buffered saline (1X PBS) and 1mM EDTA, pH 7.2 ? 7.4 with no calcium, magnesium, or preservatives present. The final protein concentration is 0.501 mg/ml.
Long Description:
Interleukin 11 (IL-11), also known as AGIF, is a member of the IL-6-type cytokine family and key regulator of multiple events in hemtaopoiesis. It stimulates growth of myeloid, erythroid and megakaryocyte progenitor cells.1 IL-11 also regulates bone metabolism, inhibits production of proinflammatory cytokines and protects against gastromucosal injury.2 Compared to other interleukins, IL-11 is relatively under-characterized. It is secreted by bone marrow stromal cells (fibroblasts) and is produced also by a number of mesenchymal cells. IL-11 is expressed in a wide variety of tissues including thymus, lung, bone, connective tissue and central nervous system. Signal transduction is initiated upon binding of IL-11 to IL-11Rα and gp130, facilitating the homodimerization of gp130 molecules.2 This permits gp130-associated JAK kinases to become activated and phosphorylate intracellular tyrosine residues on gp130. IL-11 shares many functions of IL-6 and LIF, including potentiation of megakaryocyte activity, enhancement of human myeloma cell proliferation and enhancement of hepatic acute phase protein production.3 It has been found to stimulate the T cell dependent development of specific immunoglobulin-secreting B cells.4 Clinically, IL-11 is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy. Another possible application may be as a therapeutic for osteoporosis.
NCBI Gene:
3589
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
IL-11
References
1. Williams, DA. et al. (1990) Proc. Natl. Acad. Sci. (USA) 87:7512
2. Heinrich, PC. et al. (2003) Biochem. J. 374:1
3. Bauman, H. et al. (1991) J. Biol. Chem. 266:20424
4. Curti, A. et al. (2002) Haematologica 87:373
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