Recombinant Human CXCL10
| Code | Size | Price |
|---|
| LEI-I-202-10ug | 10 ug | £273.00 |
Quantity:
| LEI-I-202-50ug | 50 ug | £625.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.4 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.4 with no calcium, magnesium, or preservatives.
Long Description:
CXCL10, also known as IP-10 and CRG-2, is a small cytokine belonging to the CXC chemokine family. Binding of this protein to the cell surface chemokine receptor CXCR3, results in pleiotropic effects, including stimulation of monocytes, natural killer and T cell migration and modulation of adhesion molecule expression. CXCL10 is secreted by several cell types in response to IFN-γ including monocytes, endothelial cells and fibroblasts (1). CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity and inhibition of bone marrow colony formation and angiogenesis (2-3). Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. CXCL10 plays a role in the regulation of tubular cell proliferation following renal ischemia-reperfusion injury (4). CXCL10 shows anti-microbial and anti-bacterial activity (5-6).
NCBI Gene:
3627
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
CXCL1
References
1. Luster, AD. et al.(1985) Nature 315: 672
2. Dufour, JH. et al.(2002) J. Immunol. 168
3. Angiolillo, AL. et al.(1995) J. Exp. Med. 182: 155
4. Kaneko, S. et al.(2008) Nephron Exp. Nephrol. 109:(1):c29-38