Recombinant Human Osteoprotegerin (OPG)
| Code | Size | Price |
|---|
| LEI-O102-25ug | 25 ug | £625.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Osteoprotegerin (OPG), also known as TNFRSF11B, is a cytokine and member of the TNF receptor superfamily that is expressed in a wide variety of tissues including adult heart, lung, kidney, liver, spleen, prostate, lymph node and bone marrow. OPG is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption.1 It specifically binds to its ligand, osteoprotegerin ligand (OPGL), which is a key extracellular regulator of osteoclast development. Therefore, OPG may provide a pharmacological tool for osteoporotic and erosive bone disorders.
NCBI Gene:
4982
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
Osteoprotegerin
References
1. Cher, ML. et al. (2007) Am J Pathol. 170(6):2100-11. PubMed
2. Schoppet, M. et al. (1980) Arteriosclerosis, Thrombosis, & Vascular Biol. 22:549
3. Kurihara, H. et al. (2002) Cytokine 18:133
4. Dunstan, CR. et al. (2001) J. Bone Miner. Res. 16:348
5. Collin-Osdoby, P. et al. (2004) Circulation Res. 95:1046
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