Recombinant Human PDGF-BB
| Code | Size | Price |
|---|
| LEI-P126-10ug | 10 ug | £477.00 |
Quantity:
| LEI-P126-50ug | 50 ug | £1,274.00 |
Quantity:
| LEI-P126-200ug | 200 ug | £2,002.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was lyophilized from a 0.2 um filtered solution in 30% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Formulation:
This recombinant protein was lyophilized from a 0.2 um filtered solution in 30% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Long Description:
Platelet-derived growth factor-BB homodimers (PDGF-BB), also known as GDGF and ODGF, is a member of the PDGF family. PDGFs are disulfide-linked dimers consisting of two polypeptide chains, designated PDGF-A and PDGF-B. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. They are stored in platelet α-granules and are released upon platelet activation. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β (1). PDGFR-α is a high-affinity receptor for each of the three PDGF forms, while PDGFR-β interacts with only PDGF-BB and PDGF-AB. PDGF functions as a local autocrine and paracrine growth factor (2). PDGF-BB plays an important role in the cellular metabolism of vascular wall by regulating the rate of M-CSF production in vascular smooth muscle cells (3). It is also a potent wound-healing hormone that accelerates incisional repair (4). PDGF-BB may induce coronary atherosclerotic disease formation by stimulating coronary artery smooth muscle cell migration and proliferation. It does that through agent-specific regulation of oxidative status and utilization of different signal transduction pathways (5). PDGF-BB is associated with excessive cell migration, proliferation and many growth-related diseases and may be a new prognostic indicator for patients with colorectal cancer (5-6).
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
PDGF-BB
References
1. Pfeilschifter, J. et al. (2005) Am. Soc. Nephrol. 10:1681 2. Claesson-Welsh, L. et al. (1991) J. Biol. Chem. 266:21138 3. Yamada, N. et al. (1992) J. Biol. Chem. 267:15455 4. Mustoe, TA. et al. (1991) J. Lab. Clin. Med. M 117:373 5. Bayraktutan, U. et al. (2008) J. Mol. Cell. Cardiol. 45:198 6. Mori, M. et al. (2008) Ann. Surg. Oncol. 15:2129
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