Recombinant Human sRANK
| Code | Size | Price |
|---|
| LEI-R142-100ug | 100 ug | £532.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Storage:
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Long Description:
RANK (Receptor Activator of Nuclear Factor κ B) is a member of the tumor necrosis factor receptor (TNFR) family, which is involved in the regulation of dendritic cell function.1 RANK is expressed on osteoclasts and their precursors, hematopoietic precursors, dendritic cells, and mammary epithelial precursors2 and is known as a regulator of development and activation of osteoclasts in bone remodeling.3 Activation of the RANK-RANKL signaling pathway is directly responsible for dramatic focal erosions that are observed in inflammatory arthritis and aseptic loosening of orthopaedic implants.4
Purity:
>98% by SDS Page and HPLC
Target:
sRANK
References
1. Higashio, K. et al. (1998) Biochem Biophys Res Commun. 253: 3952. Baron, R. et al. (2006) J clin Invest. 116: 15253. Murali, R. et al. (2004) J Biol Chem. 279: 82694. Looney, RJ. et al. (2004) J Musculoskelet Neuronal Interact 4: 276
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