Recombinant Human TNFα
| Code | Size | Price |
|---|
| LEI-T153-5ug | 5 ug | £250.00 |
Quantity:
| LEI-T153-20ug | 20 ug | £398.00 |
Quantity:
| LEI-T153-100ug | 100 ug | £989.00 |
Quantity:
| LEI-T153-2mg | 2 mg | £2,594.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Antigen Distribution:
TNF-α is secreted by macrophages, monocytes, neutrophils, T cells, B cells, NK cells, LAK cells.
Format:
This recombinant protein was lyophilized from a 0.2 um filtered solution in deionized water.
Formulation:
This recombinant protein was lyophilized from a 0.2 um filtered solution in deionized water.
Long Description:
TNF-α is a 17.5 kD protein that mediates inflammation and immunity caused by the invasion of viruses, bacteria, and parasites by initiating a cascade of cytokines that increase vascular permeability, thus bringing macrophages and neutrophils to the site of infection. TNF-α secreted by the macrophage causes the blood to clot which provides containment of the infection. TNF-α binding to surface receptors brings about various biologic activities that include cytolysis and cytostasis of many tumor cell lines In vitro, hemorraghic necrosis of tumors In vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.
NCBI Gene:
7124
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
TNF-α
References
1. Kurie, JM. et al. (2007) J Biol Chem.282(6):3507-19. Article Link2. El-Harith, EHA. et al. (2004) Saudi Med. J. 25:135 3. Adolf, GR. et al. (1990) Infect. Immun. 58:39964. Larrick, JW. et al. (1990) FASEB J. 4:32155. Sethi, G. et al. (2009) Therapeutic Targets of the TNF Superfamily 647:37
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