Recombinant Human TSLP
| Code | Size | Price |
|---|
| LEI-T142-10ug | 10 ug | £614.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Thymic stromal lymphopoietin (TSLP) is an IL-7-like epithelial cell-derived cytokine that supports differentiation and long-term growth of B cells (1). It is expressed in the heart, liver, testis and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5 but uses kinases other than the JAKs for activation. It activates DCs primed na?ve T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFα) while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation (2-3). TSLP prohibits apoptosis and stimulates growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (4).
NCBI Gene:
85480
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
TSLP
References
1. Alpers, CE. et al. (2001) Am. J. Pathol. 159:2355
2. Ziegler, SF. et al. (2007) Annu. Rev. Immunol. 25:193
3. Ziegler, SF. et al. (2005) Nat. Immunol. 6:1047
4. Gilliet, M. et al. (2003) J. Exp. Med. 197:1059
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