Recombinant Human IL-9
| Code | Size | Price |
|---|
| LEI-I-379-10ug | 10 ug | £580.00 |
Quantity:
| LEI-I-379-50ug | 50 ug | £1,422.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives present.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives present.
Long Description:
Interleukin-9 (IL-9), also known as P40, is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes (1). This cytokine stimulates cell proliferation and prevents apoptosis. IL-9 functions through the IL-9 receptor (IL-9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes (2). It enhances the proliferation of T lymphocytes, mast cells, erthroid precursor cells and megakaryoblastic leukemia cell lines. Th2 cells have historically been thought to be the source of IL-9. However, recent data suggest the existence of a Th2-related cell type that is characterized by the secretion of IL-9 and IL-10 (3). These so-called Th9 cells can differentiate from Th2 cells in the presence of TGF-β, or they can differentiate from a na?ve CD4 cell with a combination of IL-4 and TGF-β. IL-9 plays a role in the complex pathogenesis of bronchial hyperresponsiveness as a risk factor for asthma (4). Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin's disease (5).
NCBI Gene:
3578
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
IL-9
References
1. Renauld, JC. et al. (1995) J. Immunol. 154:5061
2. Yang, YC. et al. (1995) J. Biol. Chem. 270:20497
3. Veldhoen, M. et al. (2008) Nature Immunol. 9:1341
4. Levitt, RC. et al. (1997) Proc. Natl. Acad. Sci. (USA) 94:13175
5. Gruss, HJ. et al. (1992) Cancer Res. 52:1026
6. Avanzi, G. et al. (1988) Br. J. Haematol. 69:359.
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