Anti-Mouse IFNAR-1 - Purified in vivo GOLD™ Functional Grade

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Leinco Technologies
Product Code: LEI-I-401
Product Group: Primary Antibodies
CodeSizePrice
LEI-I-401-1.0mg1.0 mg£175.00
Quantity:
LEI-I-401-5.0mg5.0 mg£380.00
Quantity:
LEI-I-401-25mg25 mg£1,014.00
Quantity:
LEI-I-401-50mg50 mg£1,556.00
Quantity:
LEI-I-401-100mg100 mg£2,159.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: MAR1-5A3
Regulatory Status: RUO
Target Species: Mouse
Applications:
  • Blocking
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Flow Cytometry
  • Immunoprecipitation (IP)
  • In Vivo Assay
  • Western Blot (WB)
Shipping:
2-8°C
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Images

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Further Information

Antigen Distribution:
IFNAR1 and IFNAR2 are coexpressed on nearly all cells.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
in vivo GOLD™, Purified in vivo Functional Grade
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
This antibody was produced by In vivo genetic immunization of IFNAR1 knockout mice with a plasmid encoding the extracellular domain of murine IFNAR1.
Long Description:
IFNAR1 is a type I membrane protein, that in conjunction with IFNAR2, makes up the heterodimeric receptor that binds all type I IFNs, which includes IFN α and β. Binding and activation of the receptor stimulates Janus protein kinases, which leads to the phosphorylation of several other proteins, namely STAT1 and STAT2. IFNAR1 has also been shown to interact with PRMT1 and Tyrosine kinase 2. Type I IFNs are a family of cytokines that have been shown to promote anti-viral, anti-microbial, anti-tumor and autoimmune responses In vivo.
NCBI Gene:
15975
Purity:
?95% monomer by analytical SEC, >95% by SDS Page
Target:
IFNAR1

References

1.) Beaver, Jacob T. et al. (2020) Human Vaccines & Immunotherapeutics 16:9, 2092-2108 Article Link 2.) Theofilopoulos, AN. et al. (2012) J Immunol. 189: 000?000. Article Link 3.) Oldstone, Michael B. A. et al. (2017) Proc Natl Acad Sci U S A. 114(14): 3708?3713. PubMed 4.) Schreiber, RD et al. (2015) PLoS One.10(5):e0128636PubMed 5.) Shin, Haina et al. (2018) J Virol. 92(7): e00038-18. PubMed 6.) Crack, Peter J. et al. (2016) eNeuro 10.1523/ENEURO.0128-15.2016 Article Link 7.) Sheehan, K. C. F. et al. (2006) JICR 26(11):804 8.) Dunn, G. P. et al. (2005) Nat. Immunol. 6(7):722 9.) Fenner, J. E. et al. (2006) Nat. Immunol. 7(1):33 10). Biron, C. A. et al. (2007) J Exp Med. 204(10): 2383 11.) Raju, S et al. (2019) Cell Reports. 29(9):2556?2564.e3 Journal Link 12.) Ortiz, A. et al. (2019) Cancer Cell 35(1):33-45.e6 Journal Link 13.) Case, J. et al. (2020) Cell Host & Microbe. 28(3):465?474.e4 Journal Link 14.) Hassan, A. et al. (2020) Cell. 183(1):169?184.e13 Journal Link 15.) Hassan, A. et al. (2020) Cell. 182(3):744?753.e4 Journal Link 16.) Hassan, A. et al. (2020) Cell. 182(3):901-918.e18 Journal Link 17.) Stine, R. et al. (2019) Cell Stem Cell. 25(6):830?845.e8 Journal Link 18.) White, J. et al. (2018) Cell 175(5):1198-1212.e12 Journal Link 19.) Jagger et al. (2017) Cell Host & Microbe. 22:366?376 Journal Link 20.) Richner, J. et al. (2017) Cell 170(2):273-283.e12 Journal Link 21.) Richner, J. et al. (2017) Cell 168(6):1114-1125.e10 Journal Link 22.) Best, S. et al. (2021) Cell Reports 37(4):109888 Journal Link 23.) Diamond, M. et al. (2021) Cell 184(17):Pages 4414-4429.e19 Journal Link 24.) Ahmed, H.et al. (2021) Cell Reports 36(4): 109452 Journal Link 25.) Lebratti, T.et al. (2021) eLife 10: e65762 Journal Link 26.) Gambino Jr., F.et al. (2021) Cell Reports 35(6): 109107 Journal Link 27.) Earnest, J. et al. (2021) Cell Reports 35(1): 108962 Journal Link 28.) Desai, P. et al. (2021) Cell 184(5):1214-1231.e16 Journal Link 29.) Jagger, B. et al. (2017) Cell Host Microbe 22(3):366-376.e3 Journal Link 30.) VanBlargan, L. et al. (2018) Cell Reports 25(12):10.1016 Journal Link 31.) Lim, J. et al. (2019) eLife 8(e44452):10.7554 Journal Link

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