Recombinant Human Growth differentiation factor-3 (GDF3)
| Code | Size | Price |
|---|
| LEI-G584-20ug | 20 ug | £532.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Storage:
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Long Description:
Growth differentiation factor-3 (GDF3) also known as Vg-related gene 2 (Vgr-2), is a protein belonging to the transforming growth factor beta (TGF-β) superfamily.
It has high similarity to other TGF-β superfamily members called Vg1, BMP2, BMP6 and GDF1, but lacks one of the conserved cysteine residues common to all other TGF-β superfamily members.1 Expression of GDF3 occurs in ossifying bone during embryonic development and in the brain, thymus, spleen, bone marrow and adipose tissue of adults.2,3 GDF3 is a bi-functional protein that inhibits some TGF-β superfamily members (e.g. BMPs) while activating others, thus regulating the balance between different modes of TGF-beta signaling.4 GDF3 regulates both of the two major characteristics of embryonic stem cells: the ability to maintain the undifferentiated state and the ability to differentiate into the full spectrum of cell types.5
Purity:
>98% by SDS Page and HPLC
Target:
Growth Differentiation Factor 3
References
1. Van den Eijnden-van Raaij, A. et al. (1998) Oncogene 16: 95 2. Brown, C. et al. (2006) Development 133: 3193. Yu, L. et al. (2005) Neurosci Lett 389: 834. Brivanlou, A. et al. (2006) Cell Cycle 5: 10695. Brivanlou, AH. et al. (2006) Developement 133: 209
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