Recombinant Human IL-29
| Code | Size | Price |
|---|
| LEI-I-376-25ug | 25 ug | £580.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Interleukin-29 (IL-29), also known as IFN-λ1, is a cytokine distantly related to type I interferons and the IL-10 family. It exerts its biological effects through a receptor that also binds IL-28A and IL-28B.2 This receptor is a heterodimeric class II cytokine receptor that consists of IL-10RB and IL-28RA. IL-29 activities overlap those of type I IFNs and include anti-viral activity and up-regulation of MHC class I antigen expression.3 The expression of IL-29 is induced by virus infection or double-stranded RNA. Upon binding to the receptor, it also induces JAK kinase activation and phosphorylation of STAT and STAT2.4 IL-28 and IL-29 have recently been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells.5
NCBI Gene:
282618
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
IL-29
References
1. Sheppard, P. et al. (2003) Nat Immunol. 4(1):63-8.
2. Zitzmann, K. et al. (2006) Biochem. Biophys. Research Commun. 344:1334
3. Kotenko, SV. et al. (2003) Nat. Immunol. 4:69
4. Maher, SG. et al. (2008) Cancer Biol. Ther. 7:1109
5. Mennechet, F. et al. (2006) Immunobiology 107:4417
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