Recombinant Human OTOR
| Code | Size | Price |
|---|
| LEI-O106-5ug | 5 ug | £372.00 |
Quantity:
| LEI-O106-20ug | 20 ug | £532.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
The lyophilized protein should be stored desiccated at -20°C. For long-term storage of the reconstituted protein it is recommended to add a carrier protein such as 0.1% BSA aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Long Description:
Otoraplin, also known as OTOR is a secreted cytokine that is expressed predominantly in the cochlea of the inner ear and to a lesser extent in fetal brain and in some cartilage tissues. OTOR may play a role in chondrogenesis of the otic capsule as reduction of its expression by suitable antisense oligonucleotides causes a significant reduction in chondrogenesis.1 Otoraplin is homologous to the protein encoded by CDRAP/MIA (cartilage-derived retinoic acid sensitive protein/melanoma inhibitory activity), which is expressed predominantly by chondrocytes, functions in cartilage development and maintenance, and has growth-inhibitory activity in melanoma cell lines.2
Purity:
>95% by SDS Page and HPLC
Target:
Otoraplin
References
1. Cohen-Salmon M. et al. (2000) J of Biol. Chem. 275: 40036
2. Morton CC. et al. (2000) Genomics 66: 242