Anti-Human GDF-3
| Code | Size | Price |
|---|
| LEI-G592-100ug | 100 ug | £580.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Neutralisation
- Western Blot (WB)
Shipping:
Ambient
Storage:
The lyophilized antibody should be stored desiccated at -20°C. The reconstituted antibody can be stored for at least six weeks at 4°C. For long-term storage of the reconstituted antibody aseptically aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Conjugate/Tag/Label:
Antigen Affinity Purified
Format:
This antigen affinity purified polyclonal antibody is aseptically filtered and lyophilized from PBS with no carrier proteins or preservatives added.
Formulation:
This antigen affinity purified polyclonal antibody is aseptically filtered and lyophilized from PBS with no carrier proteins or preservatives added.
Immunogen:
Purified Recombinant Human GDF-3 (>98%)
Long Description:
Growth differentiation factor-3 (GDF3) also known as Vg-related gene 2 (Vgr-2), is a protein belonging to the transforming growth factor beta (TGF-β) superfamily.
It has high similarity to other TGF-β superfamily members called Vg1, BMP2, BMP6 and GDF1, but lacks one of the conserved cysteine residues common to all other TGF-β superfamily members.1 Expression of GDF3 occurs in ossifying bone during embryonic development and in the brain, thymus, spleen, bone marrow and adipose tissue of adults.2,3 GDF3 is a bi-functional protein that inhibits some TGF-β superfamily members (e.g. BMPs) while activating others, thus regulating the balance between different modes of TGF-beta signaling.4 GDF3 regulates both of the two major characteristics of embryonic stem cells: the ability to maintain the undifferentiated state and the ability to differentiate into the full spectrum of cell types.5
Target:
Growth Differentiation Factor 3
References
1. van den Eijnden-van Raaij A et al. (1998) Oncogene 16: 95
2. Brown C et al. (2006) Development 133: 319
3. Yu L et al. (2005) Neurosci Lett 389: 83
4. Brivanlou A et al. (2006) Cell Cycle 5: 1069
5. Brivanlou AH. et al. (2006) Developement 133: 209
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