Recombinant Human IL-28A
| Code | Size | Price |
|---|
| LEI-I-377-25ug | 25 ug | £580.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Interleukin-28A (IL-28A), also known as IFN-λ2, is a cytokine distantly related to type I interferons and the IL-10 family. It exerts its biological effects through a receptor that also binds IL-28B and IL-29 (1). This receptor is a heterodimeric class II cytokine receptor that consists of IL-10RB and IL-28RA. IL-28A activities overlap those of type I IFNs and include anti-viral activity and up-regulation of MHC class I antigen expression (2). The expression of IL-28A is induced by virus infection or double-stranded RNA. Upon binding to the receptor, it also induces JAK kinase activation and phosphorylation of STAT and STAT2 (3). IL-28A represents a potential novel approach for therapy of Th1-mediated inflammatory diseases such as T cell-mediated hepatitis (4).
NCBI Gene:
282616
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
IL-28A
References
1. Zitzmann, K. et al. (2006) Biochem. Biophys. Research Commun. 344:1334
2. Kotenko, SV. et al. (2003) Nat. Immunol. 4:69
3. Maher, SG. et al. (2008) Cancer Biol. Ther. 7:1109
4. Neurath, MF. et al. (2007) Gastroenterology 132:358
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