Anti-Mouse Interferon Gamma Antibody (Clone H22) - Purified in vivo GOLD™ Functional Grade
| Code | Size | Price |
|---|
| LEI-I-438-1.0mg | 1.0 mg | £175.00 |
Quantity:
| LEI-I-438-5.0mg | 5.0 mg | £380.00 |
Quantity:
| LEI-I-438-25mg | 25 mg | £1,014.00 |
Quantity:
| LEI-I-438-50mg | 50 mg | £1,556.00 |
Quantity:
| LEI-I-438-100mg | 100 mg | £2,159.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Hamster
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: H22
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Immunoprecipitation (IP)
- In Vivo Assay
- Neutralisation
- Western Blot (WB)
Shipping:
2-8°C
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Further Information
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
in vivo GOLD™, Purified in vivo Functional Grade
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Purified Recombinant Mouse IFN-γ (>98%)
Long Description:
Interferon-gamma (IFN-γ) or type II interferon is a dimerized soluble cytokine that is the only member of the type II class of interferons.4 It is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. IFNG is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops.5 IFN-γ has antiviral, immunoregulatory, and anti-tumour properties.6
NCBI Gene:
15978
Purity:
?95% monomer by analytical SEC, >95% by SDS Page
Target:
Interferon Gamma
References
1. Schreiber, RD. et al. (2017) Cancer Immunol Res. 5(2):106-117. PubMed
2. Diamond, MS. et al. (2017) J Virol. 91(22): e01419-17. PubMed
3. Schreiber, RD. et al. (2015) PLoS One.10(5):e0128636. PubMed
4. Goeddel, DV. et al. (1982) Nature 298: 859
5. Wilson, CB. et al. (2007) Adv. Immunol. 96: 41
6. Hume, DA. et al. (2004) J Leukoc Biol. 75: 163
7.) Winkler, E. et al. (2020) Cell 182(4):901-918.e18 Journal Link
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