Anti-Human CD119 (IFN-γ Rα Chain) - Purified in vivo GOLD™ Functional Grade
| Code | Size | Price |
|---|
| LEI-I-443-1.0mg | 1.0 mg | £175.00 |
Quantity:
| LEI-I-443-5.0mg | 5.0 mg | £380.00 |
Quantity:
| LEI-I-443-25mg | 25 mg | £1,014.00 |
Quantity:
| LEI-I-443-50mg | 50 mg | £1,556.00 |
Quantity:
| LEI-I-443-100mg | 100 mg | £2,159.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: GIR-208
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Functional Study
- In Vivo Assay
Shipping:
2-8°C
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Further Information
Antigen Distribution:
The IFN-γ receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
in vivo GOLD™, Purified in vivo Functional Grade
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Human IFN-γRα, Purified from human placenta
Long Description:
IFNγ Rα, or IFNγ R1, is a 90-100 kD type I transmembrane protein that is structurally related to IL-10 receptor. IFNγ Receptor consists of α and β chains and requires association of JAK1, JAK2 and Stat1 for IFN-γ signal transduction which induces tyrosine phosphorylation of IFN-γ Rα leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-γ induced gene transcription.
Purity:
?95% monomer by analytical SEC, >95% by SDS Page
Target:
IFNγ Rα
References
1. Schreiber, RD. et al. (2017) Cancer Immunol Res. 5(2):106-117. PubMed
2. Schreiber, RD. et al. (2015) PLoS One.10(5):e0128636. PubMed
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