Recombinant Human MMP-13
| Code | Size | Price |
|---|
| LEI-M1242-10ug | 10 ug | £671.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Polar Packs
Storage:
This recombinant protein is stable for six months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
The protein is supplied as a 0.2 um filtered solution of 25 mM MES, 10 mM CaCl2, 0.15 M NaCl, 0.05% Brij-35, pH 6.0 containing 10 ug of rhMMP-13 at a concentration of 0.2 mg/ml. It is recommended to centrifuge the vial prior to opening.
Formulation:
The protein is supplied as a 0.2 um filtered solution of 25 mM MES, 10 mM CaCl2, 0.15 M NaCl, 0.05% Brij-35, pH 6.0 containing 10 ug of rhMMP-13 at a concentration of 0.2 mg/ml. It is recommended to centrifuge the vial prior to opening.
Long Description:
Matrix metallopeptidase 13 (collagenase 3), also known as MMP13, is a glycosylated protein1 and a member of the matrix metalloproteinase (MMP) family of neutral endopeptidases, which is expressed in the skeleton during embryonic development2 and are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. MMP-13 is tightly bound to tissues and utilizes heparan sulfate proteoglycans as extracellular docking molecules. It is produced by many different cell types as an inactive proform that requires proteolytic activation to gain activity.3 Mutations causing lack of MMP-13 expression have been shown to be associated with skeletal disorders characterized by defective growth and modeling of the spine and long bones (spondyloepimetaphyseal dysplasias).4
NCBI Gene:
4322
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
MMP-13
References
1. Kn?uper, V. et al. (1996) J Biol. Chem. 271: 17124
2. Krane, SM. et al. (2004) Proc Natl Acad Sci U S A. 101(49):17192-7.
3. Woessner, JF. et al. (2000) J Biol. Chem. 275: 4183
4. Kennedy, AM. et al. (2005) J Clin. Invest. 115: 2832
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