Recombinant Mouse IL-21
| Code | Size | Price |
|---|
| LEI-I-453-10ug | 10 ug | £580.00 |
Quantity:
| LEI-I-453-1000ug | 1000 ug | £807.00 |
Quantity:
| LEI-I-453-100ug | 100 ug | £1,581.00 |
Quantity:
| LEI-I-453-25ug | 25 ug | £6,360.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Interleukin 21 (IL-21) is a T cell-derived pleiotropic cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells.1,2 This cytokine induces cell division/proliferation in its target cells. IL-21 elicits its effects on immune cells by interacting with a cell surface receptor known as the interleukin 21 receptor, IL-21R, which is expressed in bone marrow cells and various lymphocytes. IL-21 is closely related to IL-2 and IL-153 and is a key factor in the transition between innate and adaptive immune responses.4 The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies.5
NCBI Gene:
60505
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
IL-21
References
1. Foster, D. et al. (2000) Nature 408: 57
2. Clegg, CH. et al. (2002) J. Leukoc. Biol. 72: 856
3. Leonard, WJ. et al. (2002) Science 298: 1630
4. Joannopoulos, K. et al. (2003) J. Immunol. 171: 608
5. Lipsky, PE. et al. (2008) Ann Rheum. Dis. 3: 83
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