Anti-Human CARD10 (CT)
| Code | Size | Price |
|---|
| LEI-C1215-20ug | 20 ug | £199.00 |
Quantity:
| LEI-C1215-0.1mg | 0.1 mg | £591.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Shipping:
Ambient
Storage:
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Formulation:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen:
PN:C1227
Long Description:
Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, Bcl-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD10.1 This protein belongs to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules.2 CARD 10 interacts with Bcl-10, a Bcl protein that promotes apoptosis, caspase-9 maturation and activation of NF-κB.1,3 CARD 10 and the related protein CARMA1 also associate with NEMO, the regulatory subunit of the IκK complex,4 demonstrating its importance in the regulation of NF-κB transcription factor activation.
Target:
CARD10
References
1. Wang, L. et al. (2001) J. Biol. Chem. 276:21405-9. 2. Fanning, AS. and Anderson, JM. (1999) Curr. Opin. Cell Biol. 11:432-9. 3. Fischer, KD. et al. (2004) Trends Immunol. 25:113-6. 4. Stilo, R. et al. (2004) J. Biol. Chem. 279:34323-31.
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