Recombinant Human IL-1 RI
| Code | Size | Price |
|---|
| LEI-I-556-100ug | 100 ug | £887.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Interleukin-1 receptor, type I (IL1R1), also known as CD121a, is a transmembrane glycoprotein and member of the IL-1 receptor family. As important mediators involved in many immune and inflammatory responses, the agonists IL-1α and IL-1β bind to IL1R1, leading to the signal transduction and activation of NF-κ B. IL1R1 also forms a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2 which is indispensible for the signaling processes (1). IL1R1 has been shown to interact with PIK3R1, Myd88 and IL1RAP (2-4). It is expressed predominantly by T cells, fibroblasts and endothelial cells.
NCBI Gene:
3554
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
IL-1 RI
References
1. Burns, K. et al. (2006) Curr. Biol. 16:2265
2. Reddy, SA. et al. (1995) J. Biol. Chem. 272:29167
3. Burns, K. et al. (2000) Nat. Cell Biol. 2:346
4. Huang, J. et al. (1997) Proc. Natl. Acad. Sci. (USA) 94:12829
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