Anti-Human cIAP (CT)
| Code | Size | Price |
|---|
| LEI-C1250-20ug | 20 ug | £199.00 |
Quantity:
| LEI-C1250-0.1mg | 0.1 mg | £591.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Shipping:
Ambient
Storage:
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Concentration:
1.0 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Formulation:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen:
PN:C1288
Long Description:
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases.1 The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases?3, ?7.2,3 The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-α by its receptor.2,4 Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP.5 Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP.6
Target:
cIAP
References
1. Schimmer, AD. (2004) Cancer Res. 64:7183-90. 2. Goeddel, D. et al. (1995) Cell 83:1243-52. 3. Reed, JC. et al. (1998) EMBO J. 17:2215-23. < br> 4. Ashwell, JD. et al. (2002) Nature 416:345-7.
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