Anti-Human Lysosome Associated Membrane Protein-2 (LAMP-2)
| Code | Size | Price |
|---|
| LEI-L169-20ug | 20 ug | £199.00 |
Quantity:
| LEI-L169-0.1mg | 0.1 mg | £591.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Frozen Section (IHC-F)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Shipping:
Ambient
Storage:
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Formulation:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen:
PN:L171
Long Description:
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components1,2 and is negatively regulated by TOR (Target of rapamycin).3 LAMP-2, a highly glycosylated protein associated with the lysosome,4 has recently been shown to be important in autophagy as mice deficient in this protein failed to convert autophagic vacuoles into vacuoles leading to impaired degradation of long-lived proteins. This correlates with the finding that human LAMP-2 deficiency causing Danon?s disease is associated with the accumulation of autophagic material in striated myocytes. LAMP-2 exists in multiple isoforms.
Target:
LAMP-2
References
1. Gozuacik, D and Kimchi, A. (2004) Oncogene. 23:2891-906. 2. Kisen, GO. et al. (1993) Carcinogenesis 14:2501-5. 3. Shintanim, T. et al. (2000) J. Cell. Biol. 150:1507-13. 4. Gabel, CA. et al. (1990) J. Biol. Chem. 265:12036-43. 5. Suter, A. et al. (2000) Nature 406(6798):902-6. 6. Hirano, M. et al. (2000) Nature. 406(6798):906-10. 7. Fambrough, DM. et al. (1995) DNA Cell Biol. 14:863-7.
Related Products
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