Recombinant Human Angiopoietin-Like Protein-4
| Code | Size | Price |
|---|
| LEI-A325-50ug | 50 ug | £705.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Long Description:
The fasting-induced adipose factor (FIAF, ANGPTL4, PGAR, HFARP) was identified as an adipocytokine up-regulated by fasting, by peroxisome proliferator-activated receptor agonists, and by hypoxia. At the protein level, in human and mouse blood plasma, FIAF was found to be present both as a native protein and in a truncated form. Differentiation of mouse 3T3-L1 adipocytes was associated with the production of truncated FIAF, whereas in human white adipose tissue and SGBS adipocytes, only the native FIAF could be detected. Interestingly, the truncated FIAF was produced by human liver.
Experimental data suggest that FIAF is mainly presented in human blood plasma in a truncated form (FIAF-S2), whose level is increased by fenofibrate treatment. Levels of both truncated and native FIAF showed marked inter individual variation but were not associated with body mass index and were not influenced by prolonged semistarvation.
NCBI Gene:
51129
Purity:
>95% by SDS Page and HPLC
Target:
Angiopoietin-Like Protein-4
References
1. (2007) Mol. Endocrinol. Jan 9
2. (2006 Nov. 14) Proc. Natl. Acad. Sci. U.S.A. 103(46):17450
3. (2006 Sep. 8) Biochem. Biophys. Res. Commun. 347(4):1138
4. (2005 Apr. 26) Proc. Natl. Acad. Sci. U.S.A. 102(17):6086
5. (2004 Nov.) J. Lipid Res. 45(11):2071
6. (2004 May) Vet. Res. Commun. 28(4):299