Anti-Human BAFF-R (CT)
| Code | Size | Price |
|---|
| LEI-B514-20ug | 20 ug | £199.00 |
Quantity:
| LEI-B514-0.1mg | 0.1 mg | £591.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunocytochemistry (ICC)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Shipping:
Ambient
Storage:
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Concentration:
1.0 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Formulation:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen:
Purified Recombinant Human BAFF-R (>98%)
Long Description:
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4.1-4 BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion.1,2 Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kB and c-jun N-terminal kinase.4
Target:
B-Cell Activating Factor
References
1. Moore, P. A. et al. (1999) Science 285:260
2. Schneider, P. et al. (1999) J. Exp. Med. 189:1747
3. Shu, H. B. et al. (1999) J. Leukoc. Biol. 65:680
4. Mukhopadhyay, A. et al. (1999) J. Biol. Chem. 274:15978
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