Recombinant Human Neuroserpin
| Code | Size | Price |
|---|
| LEI-N175-25ug | 25 ug | £532.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Long Description:
Neuroserpin is an axonally secreted serine proteinase inhibitor that is expressed in neurons during embryogenesis and in the adult nervous system1 and is implicated in the regulation of proteases involved in processes such as synaptic plasticity, neuronal migration and axogenesis.2 Neuroserpin plays a neuroprotective role, by blocking the deleterious effects of proteolytic enzymes such as tissue plasminogen activator (tPA). A familial form of a neurodegenerative disease, termed familial encephalopathy with neuroserpin inclusion bodies, is caused by the intracellular polymerization and accumulation of mutated neuroserpin, leading to neuronal death and dementia.3
Purity:
>96% by HPLC analysis
Target:
Neuroserpin
References
1. Sonderegger, P. et al. (1998) Ame Society of Biochem. Molec. Biol. 273: 23122. Birch, NP. et al. (2002) J Neurochem. 80: 14063. Sonderegger, P. et al. (2006) Front Bioscie. 11: 33