Recombinant Human TROP-2
| Code | Size | Price |
|---|
| LEI-T404-100ug | 100 ug | £637.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.4 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.4 with no calcium, magnesium, or preservatives.
Long Description:
Trop-2 is a cell surface glycoprotein1 that is highly expressed in a wide variety of epithelial cancers. There is little or no expression of Trop-2 in adult somatic tissue.2 Trop-2 is a novel calcium signal transducer3 involved in the regulation of cell- cell adhesion.4 It is an oncogene that has potential as a therapeutic target.2 It is a possible candidate gene for diagnosis and molecular target therapy of colorectal cancer.5
NCBI Gene:
4070
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
TROP-2
References
1. Colnaghi, MI. et al. (1992) Hybridoma 11: 539
2. Michel, L. et al. (2008) Mol Cancer Ther. 7: 280
3. Alberti, S. et al. (1998) Int J Cancer 75: 324
4. Piantelli, M. et al. (2007) J Clin Oncol. 25: 10510
5. Mori, M. et al. (2006) clin Cancer Res. 12: 3057
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