Anti-Human IRF3 (CT)
| Code | Size | Price |
|---|
| LEI-I-506-20ug | 20 ug | £199.00 |
Quantity:
| LEI-I-506-0.1mg | 0.1 mg | £591.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Shipping:
Ambient
Storage:
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Formulation:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen:
PN:I-518
Long Description:
Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms (1 for review). During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-α/β genes. IRF3 is present in an inactive form in the cytoplasm of most cells.2 Following viral infection, IRF3 can be activated by IκB kinase-ε and TANK-binding kinase 1 (TBK1),3,4 whereupon IRF3 translocates to the nucleus. IRF3 can also be activated by stimulation of toll-like receptor 3 (TLR3) by dsRNA.3 IRF3 exists as at least two distinct isoforms.
NCBI Gene:
3661
Target:
IRF3
References
1. Malmgaard, L. (2004) J. Interferon & Cyto. Res. 24:439
2. Au, W. C. et al. (1995) Proc. Natl. Acad. Sci. USA 92:11657
3. Fitzgerald, K. A. et al. (2003) Nat. Immunol. 4:491
4. Sharma, S. et al. (2003) Science 300:1148
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