Anti-Human Interferon Regulatory Factor 7 (Intermediate Domain)
| Code | Size | Price |
|---|
| LEI-I-523-20ug | 20 ug | £199.00 |
Quantity:
| LEI-I-523-0.1mg | 0.1 mg | £591.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Shipping:
Ambient
Storage:
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Formulation:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Long Description:
Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms (1 for review). During infection, hostvirus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3)which can act to st imulate transcription of IFN-α/β genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including
interferon beta chain genes (2). IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling
(3,4). There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.
Target:
Interferon Regulatory Factor 7
References
1. Malmgaard, L. (2004) J. Interferon & Cyto. Res. 24:439 2. Sato, M. et al. (2000) Immunity 2000 13:539 3. Fitzgerald, KA. et al. (2003) J. Exp. Med. 198:1043 4. Honda, K. et al. (2004) Proc. Natl. Acad. Sci. USA 101:15416
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