Anti-Human MD-2 (Intermediate Domain)
| Code | Size | Price |
|---|
| LEI-M1220-20ug | 20 ug | £199.00 |
Quantity:
| LEI-M1220-0.1mg | 0.1 mg | £591.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
Ambient
Storage:
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Formulation:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen:
PN:M1224
Long Description:
MD-2 is a member of the Toll/interleukin-1 receptor (TIR)family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TLR4, the major signaling receptor for lipopolysaccharide
(LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS (5,6). The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause
mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4 (7).
Target:
MD-2
References
1. O?Neill, L. et al. (2003) Trends in Imm. 24:286 2. Vogel, SN. et al. (2003) Mol. Interv. 3:466 3. Takeda, K. et al. (2003) Annu. Rev. Immunol. 21:335 4. Janeway Jr., CA. et al. (2002) Annu. Rev. Immunol. 20:197
Related Products
| Product Name | Product Code | Supplier | MD-2 (Intermediate Domain) Blocking Peptide | LEI-M1224 | Leinco Technologies | Summary Details | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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