Recombinant Human Prolactin Receptor

Product Code: LEI-P235

Code	Size	Price

LEI-P235-50ug

50 ug

£648.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Human

Regulatory Status: RUO

Shipping:

Ambient

Storage:

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Further Information

Format:

This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.

Formulation:

This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.

Long Description:

Prolactin Receptor (PRL-R) is a cytokine receptor that lacks an intrinsic kinase domain and relies on the cytoplasmic Jak tyrosine kinases to transduce signals (1). PRL-R is required for the signaling and proliferation of prolactin (2). Prolactin receptors have been localized in a number of peripheral tissues, including tissues involved in reproduction (3). Within the immune system, multiple isoforms of PRL-R serve to mediate the effects of prolactin. These isoforms are structurally and functionally distinct, causing significant differences in ligand affinities, kinetics of transduction and the transduction proteins activated. Differential activation of these pathways may contribute to the pleiotropism of prolactin action in tissues of the immune system (4). PRL-R is required for normal maternal glucose homeostasis during pregnancy (5).

NCBI Gene:

5618

Purity:

>90% by SDS-PAGE and analyzed by silver stain.

Target:

Prolactin Receptor

References

1. Lindeman, GJ. et al. (2003) J. Biol. Chem. 278:32929 2. Clevenger, V. et al. (1998) Mol. Cell Biol. 8:896 3. Makrigiannakis, A. et al. (2005) Reproductive Biomed. 10:339 4. Clevenger, CV. et al. (2001) Lupus 10:706 5. Mastro, M. et al. (2003) J. Appl. Physiol. 94:518